This gene encodes an ~42.6kD subunit of dynactin, a macromolecular complex consisting of ~10-11 subunits ranging in size from ~22-150kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in ~8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is ~60% identical at the amino acid level to conventional actin.