Thec-Mycproteinisatranscriptionfactor,whichisencodedbythec-Mycgeneonhumanchromosome8q24.c-Myciscommonlyactivatedinavarietyoftumorcellsandplaysanimportantroleincellularproliferation,differentiation,apoptosisandcellcycleprogression.Thephosphorylationofc-MychasbeeninvestigatedandpreviousstudieshavesuggestedafunctionalassociationbetweenphosphorylationatThr58/Ser62byglycogensynthasekinase3,cyclindependentkinase,ERK2andC-JunNterminalKinase(JNK)incellproliferationandcellcycleregulation.Studiesalsohaveshownthatc-Mycisessentialfortumorcelldevelopmentinvasculogenesisandangiogenesisthatdistributebloodthroughoutthecells,andwhichbroughtextensiveattentioninthedevelopmentofnewtherapeuticapproachforcancertreatment.